Concomitant administration of theophylline and oxamniquine in rats: Effect on theophylline clearance

Abstract

This report describes an investigation into the effect of oxamniquine on systemic clearance of theophylline in rat. Male Wistar rats (N=12, 5 weeks old) were divided into 3 groups (N=4 per group) and administered buffer plus theophylline (10mg kg-1; controls, oxamniquine (5 mg kg-1;) and theophylline (10mg kg-1) or oxamniquine (20 mg kg-') and theophylline (10mg kg-1) intravenously. Theophylline clearance was estimated from a single plasma sample obtained 6 hours post drug administration. Oxamniquine administration had no effect on theophylline clearance compared to controls. It was concluded that clinically important interaction between oxamniquine and theophylline is unlikely to occur.