The Quality of Drugs Manufactured in Tanzania

Abstract

Evaluation of five quality parameters, namely friability, content, identity, disintegration and dissolution of four locally manufactured drugs in comparison with innovator brands was done. The locally manufactured drugs and the brands performed similarly in disintegration and identity of the active drug. The local samples had higher friability compared to the innovator brands. Whereas all the innovator brands passed the requirements for content of the active ingredient, only four out of eight of the analyzed local drugs met the British and United States pharmacopoeia requirements. Only one of the tested samples failed the dissolution test. In general, the innovator brands had superior dissolution profiles compared to the local drugs.