Influence of Racial Factors and Weight on Pharmacokinetic Parameters of Chloroquine Following a Single Oral Dose

  • C IA Kabati epartment of Pharmaceutics, Faculty of Pharmacy, P.O. Box 65013, Dar-es-Salaam, Tanzania
  • M HS Chambuso Department of Medicinal Chemistry, Faculty of Pharmacy, P.O. Box 65013, Dar-es-Salaam, Tanzania
  • T Mselle Department of Biochemistry, Faculty of Medicine, P.O. Box 65001, Dar-es-Salaam, Tanzania
Keywords: Chloroquine, malaria, pharmacokinetics, choroquine poisoning, dose regimen

Abstract

Pharmacokinetic parameters following a single oral dose of chloroquine were determined in African and Asian subjects. The volume of distribution and half-life showed a direct relationship to weight. The time to maximum plasma concentration (tmax) showed a significant racial variation with Asians having an average of 0.9 hours and Africans 1.89 hours. This variation may have important implications in malaria chemotherapy and the handling of cases of chloroquine poisoning. The overall results of this study suggest that individualization of chloroquine dose regimen may be necessary.

Published
2020-07-08
How to Cite
Kabati, C., Chambuso, M., & Mselle, T. (2020). Influence of Racial Factors and Weight on Pharmacokinetic Parameters of Chloroquine Following a Single Oral Dose. The East and Central African Journal of Pharmaceutical Sciences, 3(3), 66-71. Retrieved from https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/467
Issue
Vol 3 No 3 (2000): September-December 2000
Section
Articles