Chloroquine Drug Interactions Part II -- Interaction with Diuretics

  • A N Guantai Department of Pharmacology and Pharmacognosy, University of Nairobi
  • I Addae-Mensah Chemistry Department, University of Ghana
  • D K Njoroge Department of Pharmacology and Pharmacognosy, University of Nairobi
  • R W Munenge Department of Pharmacology and Pharmacognosy, University of Nairobi
Keywords: Chloroquine, furosemide, chlorthiazide, drug interaction, diuretics, kaliuresis, natriuresis

Abstract

Chloroquine, a commonly used antimalarial agent was investigated for interaction with common diuretics, furosemide and chlorthiazide. Examination of urine samples collected from water loaded rats at hourly intervals revealed that chloroquine antagonized the furosemide and chlorthiazide induced diuresis. It also decreased the natriuretic and enhanced the kaliuretic effects of furosemide and chlorthiazide.

Published
2020-07-08
How to Cite
Guantai, A., Addae-Mensah, I., Njoroge, D., & Munenge, R. (2020). Chloroquine Drug Interactions Part II -- Interaction with Diuretics. The East and Central African Journal of Pharmaceutical Sciences, 3(3), 57-60. Retrieved from https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/465
Issue
Vol 3 No 3 (2000): September-December 2000
Section
Articles