Acute Toxicity and Growth Suppression effects of the Ethanolic Extract of Cryptolepis sanguinolenta (Lindl) Shletcher

  • C Obua Makerere University, Faculty of Medicine, Department of Pharmacology and Therapeutics, P.O. Box 7072, Kampala, Uganda
  • J W Ogwal-Okeng Makerere University, Faculty of Medicine, Department of Pharmacology and Therapeutics, P.O. Box 7072, Kampala, Uganda
  • W W Anakbonggo Makerere University, Faculty of Medicine, Department of Pharmacology and Therapeutics, P.O. Box 7072, Kampala, Uganda
Keywords: Cryptolepis sanguinolenta, Asclepiadaceae, malaria, toxicity

Abstract

Cryptolepis sanguinolenta, a member of the Asclepiadaceae family, is used extensively in Africa to treat malaria and several other conditions. This study was done to evaluate the toxicity of the plant in mice and rats. The ethanolic extract of the plant was studied. The extract exhibited an LD50 of 2.08 g/kg in mice (p=0.05) with a GS50 of 0.44 g/kg in rats (p=0.05). Comparatively the compound was found to be only 1/5 as toxic as chloroquine, the standard antimalarial drug in Uganda, showing growth suppression 1/10 that of chloroquine. It was concluded that C.sanguinolenta is a safe drug that should be further developed for treatment of malaria.

Published
2020-06-08
How to Cite
Obua, C., Ogwal-Okeng, J., & Anakbonggo, W. (2020). Acute Toxicity and Growth Suppression effects of the Ethanolic Extract of Cryptolepis sanguinolenta (Lindl) Shletcher. The East and Central African Journal of Pharmaceutical Sciences, 4(3), 50-54. Retrieved from https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/399
Issue
Vol 4 No 3 (2001): September-December 2001
Section
Articles