Synthesis and Antigiardial Activity of Formononetin Analogues

  • Peggoty Mutai Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi.
  • Graziela V Rigo 2Pharmacy Faculty, Federal University of Rio Grande do Sul, Avenida Ipiranga, 2752. 90610-000. Porto Alegre, RS, Brazil
  • Tiana Tasca
Keywords: Antigiardial, Formononetin, Activity

Abstract

The synthesis and antigiardial activity of formononetin analogues is hereby reported. Formononetin, an isoflavone commonly obtained from the Leguminoseae family has previously been reported to possess antigiardial activity. In this paper, 10 analogues of formononetin were synthesized and tested for antigiardial activity. One compound was found to be active, 3 were moderately active and 6 were found to be inactive. All the 10 analogues were found to be inactive against other protozoa such as Trichomonas vaginalis and Tritrichomonas foetus.

Published
2019-03-25
How to Cite
Mutai, P., Rigo, G., & Tasca, T. (2019). Synthesis and Antigiardial Activity of Formononetin Analogues. The East and Central African Journal of Pharmaceutical Sciences, 19((1-3), 22-27. Retrieved from https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/215
Issue
Vol 19 No (1-3) (2016): January-December 2016
Section
Articles