Formulation of Furosemide Dispersible Tablets for Use in Paediatrics

Abstract

Furosemide (4 mg) dispersible tablets tailored for paediatric patients were formulated by direct compression using granulated lactose as the filler. Combinations of superdisintergrants namely sodium starch glycolate-crospovidone, sodium starch glycolate-croscarmellose and croscarmellose-crospovidone were incorporated to form three tablet batches; with a total superdisintegrant concentration of 4% w/w per tablet. The quality of the resultant tablets was evaluated using pharmacopoeial physicochemical tests. Tablets prepared with sodium starch glycolate-crospovidone and croscarmellose-crospovidone as superdisintegrants were found to comply with all specifications for tablet quality, while those formulated with sodium starch glycolate-croscarmellose, failed both the uniformity of weight and friability tests. This study showed that low dose furosemide dispersible tablets for pediatric use can be formulated using 4% w/w combinations of sodium starch glycolate-crospovidone and croscarmellosecrospovidone as superdisintegrants.