Isoniazid-Associated Uric Acid Retention in the Lizard, Uromastix hardwickii

Abstract

Reduction in uric acid excretion was observed following oral administration of 0.06 mg isoniazid per day for 5, 10 and 15 days to three groups of Uromastix hardwickii lizards. The rise of serum uric acid levels in the treated groups was 60 per cent higher on day 5, and about 4 and 5 times greater than in control groups on day 10 and 15 respectively. The rise in serum uric acid levels may be attributed to increased reabsorption or decreased excretion of uric acid in the kidneys of isoniazid-treated lizards.