Quality of Metformin Tablet Products in the Kenyan Market

  • Eunice M Kariuki Department of Pharmacy, Faculty of Health Sciences, University of Nairobi, P.O. Box 19676-00202, Nairobi, Kenya.
  • Grace N Thoithi
Keywords: Metformin, drug quality, uniformity of weight, disintegration, friability, hardness, dissolution, assay.

Abstract

The quality of 14 metformin hydrochloride tablet products locally available in the
Kenyan market is reported. The samples composed both 500 mg and 850 mg
strengths. The compendial tests performed included uniformity of weight,
disintegration, friability, hardness, assay and dissolution. Assay and dissolution
were determined by ultra-violet spectrophotometry. All the samples had a deviation
of less than ± 5% from the mean average weight in the uniformity of weight test,
disintegrated within 5-17 minutes and had a friability of less than 1%. They yielded
satisfactory hardness and acceptable dissolution within 45 minutes. However, two
samples failed to meet the British Pharmacopoeia specifications for assay.

Published
2022-06-16
How to Cite
Kariuki, E., & Thoithi, G. (2022). Quality of Metformin Tablet Products in the Kenyan Market. The East and Central African Journal of Pharmaceutical Sciences, 24(2), 85-89. Retrieved from http://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/988