The East and Central African Journal of Pharmaceutical Sciences https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps <p>The East and Central African Journal of Pharmaceutical Sciences is a peer-reviewed scientific journal housed in the Department of Pharmaceutical Chemistry, Pharmaceutics and Pharmacognosy, University of Nairobi, Nairobi, Kenya. It is dedicated to all aspects of Pharmaceutical Sciences research and is published in English.</p> Department of Pharmaceutical Chemistry, Pharmaceutics and Pharmacognosy, University Of Nairobi en-US The East and Central African Journal of Pharmaceutical Sciences 1026-552X Editorial: On the Utility and Safety of Food Additives https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/2701 <p>A food additive is any substance that is deliberately added to foods to yield specific desirable effects such<br>as preservation and organoleptic attributes. These conferred attributes are crucial in the marketability,<br>acceptability, aesthetics, shelf life and value enhancement of foods. Food additives have been in use by<br>mankind since antiquity. The Egyptians coloured food with saffron, while the Romans added alum<br>(potassium aluminum sulfate) to whiten it. Interestingly, in the 19th century, bakers in England used alum<br>to make bread whiter and bulkier. The Indians used spices (curries) in food preservation and traded in the<br>same with other continents, thus resulting in the renowned inbound caravans from Europe. Salting was so<br>effective and highly valued to the extent of being applied as ‘payment/wages’ among the Romans.<br>Actually, the word ‘salary’ bears its etymology (Roman, ‘sal’) form this practice. The deliberate use of<br>salt to preserve fish and meat, through dehydration was commonly used in diverse cultures. Traditional<br>methods for food preservation include pickling with vinegar, salting, smoking, sugaring and<br>alcoholization.</p> Kennedy O Abuga ##submission.copyrightStatement## 2025-02-28 2025-02-28 27 1 1 2 High Potassium Bromate Levels in Bread Brands marketed in Mwanza and Kagera regions of Tanzania: A Cross-Sectional Study https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/2702 <p>Bread production often involves the addition of potassium bromate to enhance<br>product quality. The study analyzed potassium bromate levels in bread brands<br>from Mwanza and Kagera regions, Tanzania. This analysis was conducted due to<br>the carcinogenic risks associated with potassium bromate when it exceeds the<br>US-FDA's permissible concentration of 0.02 mg/kg. Twenty-one bread samples<br>were randomly collected from the study areas and analyzed for potassium<br>bromate content using David Pearson’s qualitative and quantitative methods at<br>the Tanzania Bureau of Standards laboratories. The results obtained showed<br>that all samples contained potassium bromate, with concentrations ranging from<br>1.02 - 4.85 μg/g, which is significantly above the permissible limit. Consequently,<br>all brands tested are unsafe for human consumption due to excessive bromate<br>levels. This indicates a significant public health risk and underscores the need for<br>stricter regulatory enforcement to ensure adherence to food safety standards.</p> Rosemary Magoiga Erick Kajuna Eugene Mutagwaba Tanga Mafuru James Kapala Raphael Matinde Adelina Thomas Emmanuel Kimaro Ambrose Haule Eliangiringa Kaale ##submission.copyrightStatement## 2025-02-28 2025-02-28 27 1 3 7 Quality Evaluation of Oxytetracycline Injection and Water Soluble Powder Veterinary Products Marketed in Nairobi City, Kenya https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/2703 <p>The antibiotic oxytetracycline is extensively applied in veterinary medicine in<br>diverse formulations including injectable solution, water soluble powder and<br>wound sprays. The drug is liable to degradation during processing and shelf life,<br>which may compromise its quality attributes. A survey on the quality of<br>oxytetracycline injection and water soluble powder products available in<br>agroveterinary (agrovet) and pharmacy stores in Nairobi city, Kenya was<br>carried out. Thirteen injectable and 11 water soluble powder samples were<br>subjected to British Pharmacopoeia and United States Pharmacopeia quality<br>specifications. Whereas all the injections complied with assay specifications, only<br>three complied with colour of solution and none complied with pH specification.<br>Furthermore, all water soluble powder samples failed the pH test, while two did<br>not comply with assay specifications. The results obtained demonstrate the<br>existence of substandard oxytetracycline products in the study area. Proper<br>adherence to good manufacturing and distribution practices as well as post<br>market surveillance studies are required to ensure optimal quality of veterinary<br>drugs in the market.</p> Shakina Y Otieno Abdinasir A Mohamed Hannington N Mugo Kennedy O Abuga ##submission.copyrightStatement## 2025-02-28 2025-02-28 27 1 8 13 Isolation and Antioxidant Activity of Harmalol from Grewia villosa Willd. Stem and Root Bark https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/2694 <p><strong><em>Grewia villosa</em></strong><strong> Willd. is a deciduous shrub found in arid parts of Kenya and used as both food and medicine. The study aimed to isolate compounds present in <em>Grewia villosa</em> stem and root bark extract and assess their antioxidant activity. <em>Grewia villosa</em> stem and root bark were collected from Loitokitok, Kajiado County, Kenya. They were dried in the shade, pulverized to fine powder, and extracted in methanol/dichloromethane 1:1 mixture for 72 h. The solvent was removed by rotary evaporation. The crude extract was subjected to column chromatography over silica gel to obtain one pure compound. Analysis by mass spectrometry and </strong><strong>nuclear magnetic resonance spectroscopy identified the isolated pure compound as 1-methyl-4,9-dihydro-3H-β-carbolin-7-ol (harmalol). Antioxidant activity was performed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) standard protocol. Harmalol displayed significant antioxidant activity (115.22 µg/ml) comparable to that of the methanol extract. This compound was previously isolated from the root of <em>G. villosa</em> but was not fully characterized spectroscopically. This study is the first report of NMR characterization of harmalol.</strong></p> Julia Kimondo Peggoty Mutai Peter Njogu Charles Kimwele Purity Ochieng Abiy Yenesew ##submission.copyrightStatement## 2025-03-01 2025-03-01 27 1 14 19 Determinants of non-Adherence among Tuberculosis Patients on Treatment at Mbagathi County Hospital, Nairobi, Kenya https://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/2704 <p>Tuberculosis is one of the leading causes of mortality globally. Non-adherence leads<br>to development of drug resistance, treatment failure and relapse, increased<br>transmission of the bacilli and prolonged morbidity and mortality. A cross-sectional<br>study with a sample of 138 participants, selected by simple random sampling,<br>interviewed using a structured questionnaire was implemented. Telephone<br>interviews on patients who were identified as lost to follow up was conducted. Data<br>was populated in an Excel sheet and analyzed descriptively and inferentially via<br>logistic regression using Stata version 13 software. A total of 137 tuberculosis<br>patients was enrolled, two thirds of whom were males, with a median age of 32 (IQR<br>25,42). The prevalence of non-adherence was 7.30% (n=10). Medication complexity<br>(aOR 14.67, 95% CI 2.44-88.07, p =0.003) and forgetting to take medications (aOR<br>9.11, 95% CI 1.16-71.54, p =0.036) were the main determinants associated with nonadherence.<br>Attention should be devoted to these factors by finding means to help<br>patients remember to take their medications and adopting fixed dose combinations<br>and pill organizers to reduce medication complexity.</p> Jackline M Kathomi George A. Mugendi Judith A Odenyo ##submission.copyrightStatement## 2025-03-01 2025-03-01 27 1 20 26